Translation to Human and Veterinary Clinics
Translational Models
Our goal is to move biofabrication-based technologies towards clinically relevant applications in both human and veterinary medicine. This requires models, materials and implants that are not only biologically promising, but also mechanically robust, scalable and suitable for translation. Close interaction between engineers, biologists, clinicians and veterinarians is essential to ensure that new technologies address real clinical needs.
We develop in vitro and ex vivo systems that more closely mimic the native tissue environment. These include inflammatory cartilage models, osteochondral systems, organ-on-chip platforms and bioreactor-based approaches for studying tissue maturation, disease mechanisms and treatment responses. Such models allow us to evaluate regenerative strategies under controlled yet physiologically relevant conditions, while helping to reduce reliance on animal experiments.
Translation also depends on reproducible manufacturing and clinically aligned development pathways. Through patient-specific implant design, advanced therapy development and scalable biofabrication workflows, we aim to support the progression from experimental constructs to safe, effective and clinically applicable regenerative treatments. The Innovation Center for Advanced Therapies (ICAT) provides an important translational environment for this work, supporting the development of advanced therapy medicinal products, quality-controlled production strategies and routes towards clinical implementation. This includes attention to standardisation, quality control, regulatory requirements and scalable manufacturing approaches that can ultimately support implementation in both human and veterinary clinical settings.
LLarge-animal and veterinary studies play an important role in this translational pathway. Equine and other clinically relevant models provide joint size, loading conditions and tissue characteristics that help bridge the gap between laboratory research and human application. At the same time, veterinary patients may benefit directly from regenerative strategies for cartilage, bone and osteochondral repair, creating opportunities for mutual progress in human and animal health.